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Particle Analysis and Laser Diffraction for Providing Effective Pharmaceutical Standards

Written by admin on . Posted in Analytical method development, Analytical method validation guidelines, Electron microscopy sciences

Laser diffraction analysis

Traditionally, particle size analysis was conducted using sieving and sedimentation. Over the past 2 decades, however, laser diffraction has significantly replaced these traditional methods.

Particle Sizing and Sieving

This method for providing an analysis of particle size is the oldest in use. It continues to be used, however, for measuring relatively large particles of approximately 1 millimeter.

Particle Sizing and Laser Diffraction Analysis

This method of sizing is especially used for particles that range in size from 0.5 to 1000 microns. Basically, when a laser’s light beam is scattered by a group of particles, the angle at which it scatters is inversely proportional to the size of the particle. In other words, the smaller the particle, the larger the an